Low uptake on PET & malignancy
Benign and malignant pulmonary lesions usually are differentiated by 18F-FDG PET with a semiquantitative 18F-FDG standardized uptake value (SUV) of 2.5. However, the frequency of malignancies with an SUV of less than 2.5 is significant, and pulmonary nodules with low 18F-FDG uptake often present diagnostic challenges. These results suggested that for solid pulmonary lesions with low 18F-FDG uptake, semiquantitative approaches do not improve the accuracy of 18F-FDG PET over that obtained with visual analysis. Pulmonary lesions with visually absent uptake indicate that the probability of malignancies is very low. In contrast, the probability of malignancy in any visually evident lesion is about 60%.
Reference-Accuracy of PET for Diagnosis of Solid Pulmonary Lesions with 18F-FDG Uptake Below the Standardized Uptake Value of 2.5
Journal of Nuclear Medicine Vol. 47 No. 3 426-431
Low uptake on PET & malignancy
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Reviewed by Sumer Sethi
on
Tuesday, January 23, 2007
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Sumer Sethi
Unique blend of academic excellence and entrepreneurship, heading leading firms in India- Teleradiology Providers, pioneering company providing teleradiology services and DAMS (Delhi Academy of Medical Sciences) Premier test preparation institute in India for MD/MS/MCI preparation. He has also been an invited faculty member at various conferences, including Teleradiology in IRIA 2008 and 2011, Hospital Build Middle East, Congress of the Brain Tumor Radiology in Neuro-oncology Society. Dr. Sethi is Editor-in-Chief of Internet Journal of Radiology. He has a keen interest in Web 2.0 technologies and in maintaining his famous radiology blog, which has been featured in multiple international journals.
2 comments:
In contrast, the probability of malignancy in any visually evident lesion is about 60%
I practice in a locale with coccidiomycosis. There are great numbers of benign lung nodules with mild to moderate FDG accumulation. In fact, I have such a lung nodule myself. Our positive predictive value is nothing like 60%. Maybe 30 or 40% would be more like it.
I had a pet scan that stated mild uptake, but yet lesion has a SUV of 4.9. Even with an SUV of 4.9 can this be inflamation or scar tissue?
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