Carcinoma Prostate-Osteoblastic Metastases

The balance between the activities of osteoblasts  and osteoclasts determines the phenotype of metastatic bone lesions, and both osteoblasts and osteoclasts have been implicated — directly or indirectly — in bone metastasis.  Metastases from prostate cancer, most of which are adenocarcinomas, nearly always form osteoblastic lesions in bone; by contrast, bone metastases from kidney, lung or breast cancers more often are osteolytic. This is 61 year old male known case of ca prostate with extensive osteoblastic secondaries seen in plain film and CT sections clearly.  Other causes of osteoblastic secondaries are breast, stomach, carcinoid, TCC bladder.