Concept of Enhancement in Brain Lesions-For the Beginners
Why do some tumours enhance and some don't?
Answer to this question lies in the concept of Blood brain barrier. The brain has a unique triple layered blood-brain barrier (BBB) with tight endothelial junctions in order to maintain a consistent internal homeostatis. Contrast will not leak into the brain unless this barrier is damaged.
Enhancement is seen when a CNS tumor destroys the BBB.
Extra-axial tumors such as meningiomas and schwannomas are not derived from brain cells and do not have a blood-brain barrier. Therefore they will enhance. There is also no blood-brain barrier in the pituitary, pineal and choroid plexus regions as these are normally out of BBB.
Concept of Enhancement in Brain Lesions-For the Beginners
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Reviewed by Sumer Sethi
on
Thursday, January 05, 2012
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Sumer Sethi
Unique blend of academic excellence and entrepreneurship, heading leading firms in India- Teleradiology Providers, pioneering company providing teleradiology services and DAMS (Delhi Academy of Medical Sciences) Premier test preparation institute in India for MD/MS/MCI preparation. He has also been an invited faculty member at various conferences, including Teleradiology in IRIA 2008 and 2011, Hospital Build Middle East, Congress of the Brain Tumor Radiology in Neuro-oncology Society. Dr. Sethi is Editor-in-Chief of Internet Journal of Radiology. He has a keen interest in Web 2.0 technologies and in maintaining his famous radiology blog, which has been featured in multiple international journals.
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