Donepezil PET-Notes
#Parkinson's disease is associated with early parasympathetic dysfunction leading to constipation and gastroparesis. The positron emission tomography tracer 5-[(11)C]-methoxy-donepezil was recently validated for imaging acetylcholinesterase density in the brain and peripheral organs.
#Donepezil is a high-affinity ligand for #acetylcholinesterase-the enzyme that catabolizes acetylcholine in cholinergic synapses. Decreases in (11)C-donepezil binding may, therefore, represent a marker of parasympathetic denervation of internal organs.
Donepezil PET-Notes
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Reviewed by Sumer Sethi
on
Monday, March 16, 2015
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Sumer Sethi
Unique blend of academic excellence and entrepreneurship, heading leading firms in India- Teleradiology Providers, pioneering company providing teleradiology services and DAMS (Delhi Academy of Medical Sciences) Premier test preparation institute in India for MD/MS/MCI preparation. He has also been an invited faculty member at various conferences, including Teleradiology in IRIA 2008 and 2011, Hospital Build Middle East, Congress of the Brain Tumor Radiology in Neuro-oncology Society. Dr. Sethi is Editor-in-Chief of Internet Journal of Radiology. He has a keen interest in Web 2.0 technologies and in maintaining his famous radiology blog, which has been featured in multiple international journals.
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