Intracranial Gadolinium Deposition-Study Reports

According to a study by researchers from Mayo, Rochester published in  Online edition of Radiology, intravenous Gadolinium exposure is associated with neuronal tissue deposition in the setting of relatively normal renal function.  In this study, signal intensities from T1-WI and postmortem neuronal tissue samples from 13 patients who underwent at least four GBCA (Gadolinium-based contrast agents) -enhanced brain MR examinations between 2000 and 2014 (contrast group) were compared with those from 10 patients who did not receive GBCA (control group). 

Compared with neuronal tissues of control patients, all of which demonstrated undetectable levels of gadolinium, neuronal tissues of patients from the contrast group contained 0.1–58.8 μg gadolinium per gram of tissue, in a significant dose-dependent relationship that correlated with signal intensity changes on precontrast T1-weighted MR images. Additional studies are needed to investigate the clinical significance of these findings and the generalizability to other Gadolinium-based contrast agents.

Reference 

Intracranial Gadolinium Deposition after Contrast-enhanced MR Imaging

Robert J. McDonald, Jennifer S. McDonald, David F. Kallmes, Mark E. Jentoft, David L. Murray, Kent R. Thielen, Eric E. Williamson, and Laurence J. Eckel

Radiology Ahead of Print. DOI: http://dx.doi.org/10.1148/radiol.15150025