The Why behind "Warburg" Effect
Ever wondered why cancer cells undergo Warburg effect , aerobic glycolysis?
The why behind it.
This interesting paper explores this question. Learning about science unraveling these mysteries is always a pleasure.
According to the article
Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is associated with proliferation across many organisms and conditions.
- PDH activation suppresses cell proliferation by reducing the NAD+/NADH ratio
- Insufficient ATP demand slows mitochondria NAD+ regeneration in proliferating cells
- Uncoupling mitochondrial respiration from ATP synthesis can increase proliferation
- Aerobic glycolysis reflects increased cell demand for NAD+ relative to ATP turnover
Reference : Increased demand for NAD+ relative to ATP drives aerobic glycolysis
Alba Luengo et al
Published:December 30, 2020 DOI: https://doi.org/10.1016/j.molcel.2020.12.012
The Why behind "Warburg" Effect
Reviewed by Sumer Sethi
on
Thursday, January 21, 2021
Rating:
Reviewed by Sumer Sethi
on
Thursday, January 21, 2021
Rating:
Sumer Sethi
Unique blend of academic excellence and entrepreneurship, heading leading firms in India- Teleradiology Providers, pioneering company providing teleradiology services and DAMS (Delhi Academy of Medical Sciences) Premier test preparation institute in India for MD/MS/MCI preparation. He has also been an invited faculty member at various conferences, including Teleradiology in IRIA 2008 and 2011, Hospital Build Middle East, Congress of the Brain Tumor Radiology in Neuro-oncology Society. Dr. Sethi is Editor-in-Chief of Internet Journal of Radiology. He has a keen interest in Web 2.0 technologies and in maintaining his famous radiology blog, which has been featured in multiple international journals.
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